Does this battery work in a 2018 Ford 250?

Hello, no, your 2018 Ford F250 takes a BCI group 65 battery. I would recommend going with a higher CCA rated option, like 850CCA. Here is a link to the many options we carry: https://www.battsys.com/product-finder/pf-automotivelightduty?find=2018-ford-f-250-super-duty-6-2-liters-379-cid-v8-ex--xl-750--2727054&sid=7Q1HcrbIro If you have any questions, please let us know.